Download Histamine, Serotonin and Ergot Alkaloids PDF

TitleHistamine, Serotonin and Ergot Alkaloids
Tags Drugs Serotonin Receptor Antagonist Neurochemistry
File Size4.1 MB
Total Pages36
Document Text Contents
Page 19

Histamine Receptor Antagonists

1. Sedation

- Resemble that of antimuscarinic drugs

- “sleep aids”

- Ordinary dosage: children manifest excitation rather than sedation

- Marked stimulation, agitation, convulsion at very high toxic levels

2. Antinausea and antiemetic actions

- Motion sickness

- doxylamine (in bendectin) as treatment in the past

3. Antiparkinsonism effect

- diphenhyramine

4. Anticholinoreceptor actions

- Fist generation agents i.e. ethonalamine & ethyldiamine

- Reported benefits for nonallergic rhinorrhea

- Causes urinary retention and blurred vision

H1 Receptor Antagonist: PHARMACODYNAMICS

Other actions of H1 receptor antagonist aside from blocking histamine

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