Download NBDE Part I Biochem Review and Study Guide PDF

TitleNBDE Part I Biochem Review and Study Guide
TagsGlycogen Mitochondrion Glycolysis Earth & Life Sciences
File Size364.3 KB
Total Pages35
Table of Contents
                            Examination Specifications (2002)1
	Building Blocks of Life Course (41)
		Integrated Biochemistry Review and Study Questions
			PHYSICAL-CHEMICAL PRINCIPLES (3)
			BASIC PRINCIPLES
			E. Ph—OH
				AMINO ACIDS AND PROTEINS
				INTERDISCIPLINARY CLINICAL/CROSS CORRELATIONS
D. methylglyoxal.
	* D. 1 = couples 2 = exergonic
	A. Glycogen is composed of highly branched chains of glucose residues.
	Related study questions
	A. NAD+
	Related study questions
	D. phosphorylase a
		B. polysaccharides that unfold DNA supercoils interfering with chromosome replication.
	D. DNA polymerase I (Kornberg) and DNA ligase
D. B12 cobalamin : pernicious anemia
	B. dihydrofolate
B. vitamin C : scurvy
E. folate : anemia
E. treat blood leukemia disorders.
	C. hormones
	D. fibronectins
	A. Only choline
		C. tryptophan decarboxylase
		D. glycine decarboxylase
	B. Both are inside cells.
	C. Both contain Fe2+ combined with porphyrin.
D. lipoic acid
National Board Part I Examination Specifications (2002)
	Building Blocks of Life Course (41)
                        
Document Text Contents
Page 1

2003 Biochemistry Review for the National Boards Part I Page 1 of 35
©2003 Gene C. Lavers, Ph.D.

Examination Specifications (2002)1

Building Blocks of Life Course (41)

I. Physical-Chemical Principles (3)
A. Basic principles (2)
B. Applied principles (1)

II. Biological Compounds (9)
A. Sugars and carbohydrates (1)
B. Amino Acids and proteins (2 )
C. Lipids (1)
D. Nucleic Acids and metabolism (1)
E. Interdisciplinary clinical/cross correlation (4)

III. Metabolism (13)
A. Bioenergetics (1)
B. Enzymology (1)
C. Catabolism (2)
D. Anabolism (2)
E. Regulation (2)
F. Interdisciplinary clinical/cross correlation (5)

---25 ---
IV. Molecular Biology (8)

A. DNA/RNA and protein synthesis (4 )
B. Genetic engineering (2)
C. Interdisciplinary clinical/cross correlation (2)

XIV. Nutrition (8)
A. Nutrients/minerals (3)

1. Requirements (1)
2. Functions (2)

B. Interdisciplinary and clinical/cross correlation (2)

---16 of 25 ---

---9 of 25 ---

Biochemistry in other D1 Courses (13)

V. Connective Tissues (8) (in Basic Tissues)
A. Soft tissue (2)
B. Hard Tissue/calcification (3)
C. Interdisciplinary and clinical/cross correlation (3)

VI. Membranes (4) (most in Cell Organelles )
A. Structure (1)
B. Function (1)
C. Interdisciplinary clinical/cross correlation (2)

VII. Nervous System (9) (most in Organ Systems)
A. General properties (2)
B. Central nervous system (1)
C. Autonomic nervous system (1)
D. Somatic nervous system (with reflexes) (2)
E. Special senses (1)
F. Interdisciplinary and clinical/cross correlation (2)

VIII. Muscle (6) ()
A. Skeletal (2) metabolism and myoglobin
B. Smooth (1)
C. Cardiac (1)
D. Interdisciplinary and clinical/cross correlation (3)

IX. Circulation (9) (in Basic Tissues/clotting/gas transport
A. Fluid content and dynamics (2)
B. Coagulation (1)
C. Cardiodynamics and electrophysiology (2)
C. Regulation (1)
D. Interdisciplinary and clinical/cross correlation (3)

X. Respiration (6) (in Basic Tissues)
A. Mechanical aspects (1)
B. Gas exchange and transport (1)
C. Regulation (1)
D. Interdisciplinary and clinical/cross correlation (3)

XI. Renal (6) (see Organ Systems)
A. Functional anatomy (1)
B. Blood flow and filtration (1)
C. Reabsorption and secretion (1) metabolites
D. Interdisciplinary and clinical/cross correlation (2)

XII. Acid-Base Balance (1) (in Organ Systems)
XIII. Digestion (5) (in Organ Systems)

A. Neuromuscular (1)
B. Secretions (1) enzymes
C. Absorption (1)
D. Regulation (1)
E. Interdisciplinary and clinical/cross correlation (1)

XV. Endocrines (8) (in Organ Systems)
A. Pituitary/hypothalamus (1)
B. Reproduction (1)
C. Signaling systems (2) insulin/glucagon & cAMP
D. Pancreas/parathyroid (1)
E. Adrenal/thyroid (1)
F. Interdisciplinary and clinical/cross correlation (2)

Page 2

2003 Biochemistry Review for the National Boards Part I Page 2 of 35
©2003 Gene C. Lavers, Ph.D.

Integrated Biochemistry Review and Study Questions

To assist you in reviewing Biochemistry for the Part I National Boards, review questions were prepared and are accompanied
by suggested study or thought questions in red text. Additionally, written answers - as endnotes - are provided to foster easier
review rather than new learning. To see the answer, move the mouse cursor over the endnote number (exponent) and the
endnote pops up. Greek letters, super/subscripts formatting are lost in the popup note, so consult the actual endnote as needed.
[Additional information is within brackets in grey tone, which is also lost in the popup note.].
The TOPIC headings (centered) and their SUBTOPIC headings (left margin) are also in gray scale. Topics in Building
Blocks of Life course are in blue text. Other topics taught in the previous traditional biochemistry course are in other D1
courses, these other topics are in green text. Many subtopics can not be included in a short 50 question format, so the related
study questions attempt to expand the subtopics in the questions. Not all answers (*) are reviewed or discussed in the endnote
material.


PHYSICAL-CHEMICAL PRINCIPLES (3)

BASIC PRINCIPLES
1. Which of the following functional groups behaves as a weak acid, i.e., dissociate a proton in aqueous solution, at

physiological pH?
A. R—CH2—R'
B. RCH2—OH
C. R—NH3+

* D. R—COOH
E. Ph—OH

Related study questions.
[1] What is physiological pH?2 What is a weak acid compared to a strong acid?3

[2] Identify each functional group above, which can dissociate at physiological pH; and why4?
[3] Why is the pKa of –COOH and –NH2 on the α-carbon of amino acids about 1-2 pH unit higher and lower, respectively5?

2. Which of the following pairs of compounds is INCORRECTLY matched with its respective type of stereoisomerism?
A. D- and L–glyceraldehyde : absolute configuration
B. α– and β-glucose : anomer pair
C. glucose and mannose : epimers
D. cis- and trans–fumarate : geometric isomers

* E. ribose and glucose : diastereomers

Related study questions.
[1] How many configurations can an asymmetric tetrahedral carbon and a chiral carbon have6? How many different

configurations do all of the asymmetric carbons (C*) contribute in a sugar?7 How many C* in aldoses8; ribose, glucose,
and mannose; in ketoses9: ribulose, xylulose, fructose?

[2] Regarding carbons C1–C5 or C1–C6, which chiral carbons in those sugars define pairs of anomers (α/β)10, epimers11 (e.g.,
glucose and mannose) , D/L-sugar families12 (e.g., D/L-glucose).

[3] How many of the asymmetric carbon atoms of these sugars rotate polarized light, i.e., are optically active?13 If a D-sugar
always give a (+) optical rotation does the corresponding mirror image L-sugar always give a (–) rotation?14 Is there any
consistent relationship between the asymmetrical tetrahedral carbons and the direction (+ or –) of optical light rotation
properties?15

[4] What are meso stereoisomers versus diastereoisomer?16 Cite an example17.

APPLIED PRINCIPLES
3. Which thermodynamic parameter deals with randomness and disorder?

A. enthalpy
* B. entropy

C. free energy
D. activation energy
E. potential energy

Related study questions.
[1] What is the meaning of each the terms listed18?
[2] What is the significance of random disorder versus specified order in biological systems19?

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